Enhertu is used by healthcare professionals to treat patients with unresectable or metastatic HER2-positive breast cancer. Enhertu single-use vials come in 100 mg to administer intravenously. Fam-trastuzumab deruxtecan-nxki is a HER2-directed antibody and topoisomerase inhibitor conjugate. Fam-trastuzumab deruxtecan-nxki is an antibody-drug conjugate (ADC) composed of three components:
a humanized anti-HER2 IgG1 monoclonal antibody (mAb), covalently linked to a topoisomerase inhibitor, via
A tetrapeptide-based cleavable linker. Deruxtecan is composed of a protease-cleavable maleimide tetrapeptide linker and the topoisomerase inhibitor, DXd, which is an exatecan derivative.
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